See the DrugPatentWatch profile for valsartan
Valsartan is manufactured by several pharmaceutical companies. In the United States, the primary manufacturers of generic valsartan include Teva Pharmaceuticals, Mylan (now Viatris), and Aurobindo Pharma [1].
Who else makes valsartan?
Globally, numerous companies produce valsartan, often through generic versions. Companies like Novartis, the originator of the drug under the brand name Diovan, continue to market it in various regions, though the patent for the original formulation has expired in many markets [2]. Other generic manufacturers globally include Torrent Pharmaceuticals, Dr. Reddy's Laboratories, and Cipla [1].
When does valsartan's patent expire?
The original patent for valsartan (Diovan) has expired in major markets, allowing for the widespread availability of generic versions. For instance, patent expiries in the United States and Europe have facilitated generic competition [2]. Specific patent expiry dates can vary by country and formulation, with many key patents having lapsed by the late 2000s and early 2010s [3].
Why was valsartan recalled?
Certain batches of valsartan were recalled in 2018 due to the detection of N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA), which are probable human carcinogens. These impurities were found in valsartan products manufactured by specific companies, leading to widespread recalls of products made by multiple manufacturers, including those supplied by the Chinese company Zhejiang Huahai Pharmaceutical [4][5].
How does valsartan work?
Valsartan is an angiotensin II receptor blocker (ARB). It works by blocking the action of angiotensin II, a chemical that narrows blood vessels. By preventing angiotensin II from binding to its receptors, valsartan causes blood vessels to relax and widen, which lowers blood pressure and reduces the workload on the heart [6].
What conditions is valsartan used to treat?
Valsartan is prescribed to treat high blood pressure (hypertension) and heart failure. It is also used in patients who have had a heart attack to improve survival [6].