Can you take Advil (ibuprofen) with amoxicillin?
Yes. Advil (ibuprofen) and amoxicillin are commonly used together, and there is no well-known direct drug interaction between them.
Why people take them together
Amoxicillin treats bacterial infections, while ibuprofen helps with symptoms such as fever, pain, and inflammation. Using both can let the antibiotic work on the infection while ibuprofen improves how you feel.
Are there any situations where ibuprofen should be avoided?
Even though the combo is generally considered safe, ibuprofen may not be a good choice if you have certain risks, such as:
- A history of stomach ulcers or gastrointestinal bleeding
- Significant kidney disease or dehydration
- Allergy to NSAIDs (ibuprofen/naproxen/aspirin-type medicines)
- Taking blood thinners or other medicines that increase bleeding risk
In those cases, ask a clinician or pharmacist whether acetaminophen (paracetamol) is a safer option.
What to watch for while taking amoxicillin
If you develop signs of an allergy to amoxicillin (hives, swelling of the face/lips, trouble breathing), stop and seek urgent help. Also contact a clinician if you get severe or persistent diarrhea, which can happen with antibiotics.
Practical guidance
- Take amoxicillin exactly as prescribed (dose and schedule).
- Use Advil only as directed on the label (or by a clinician), and with food if you’re prone to stomach upset.
- If symptoms are not improving after 48–72 hours of antibiotics, or you get worsening fever, pain, or new symptoms, contact a healthcare professional.
Sources
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