Invokana, a brand-name medication, does not currently have a generic version available on the market. The drug, prescribed for type 2 diabetes, is manufactured by Janssen Pharmaceuticals [1].
When might a generic version of Invokana become available?
The availability of a generic version of Invokana depends on patent expirations and potential legal challenges to those patents. Drug patents typically grant market exclusivity for a period, preventing generic competition. For Invokana (canagliflozin), its primary patents and exclusivity periods may be nearing expiration, but precise dates can be complex due to various factors, including different patent types and potential litigation. Information regarding specific patent dates and challenges can be found on resources like DrugPatentWatch.com [2].
What is Invokana used for?
Invokana is a medication used to improve blood sugar control in adults with type 2 diabetes. It is part of a class of drugs called SGLT2 inhibitors. In addition to lowering blood sugar, Invokana has also been shown to reduce the risk of major cardiovascular events, such as heart attack or stroke, in certain patients with type 2 diabetes and established cardiovascular disease [1]. It is also indicated to reduce the risk of end-stage kidney disease, worsening kidney impairment, cardiovascular death, and hospitalization for heart failure in patients with type 2 diabetes and diabetic kidney disease [1].
How do SGLT2 inhibitors like Invokana work?
SGLT2 inhibitors, including Invokana, work by targeting a protein in the kidneys called sodium-glucose cotransporter 2 (SGLT2). This protein is responsible for reabsorbing most of the glucose filtered by the kidneys back into the bloodstream. By inhibiting SGLT2, Invokana reduces this reabsorption, causing more glucose to be excreted in the urine. This process helps to lower blood glucose levels [1].
Are there other SGLT2 inhibitors available?
Yes, there are other SGLT2 inhibitors available on the market, which may offer alternatives for patients with type 2 diabetes. These include drugs like Farxiga (dapagliflozin) and Jardiance (empagliflozin), among others [1].
What are the potential side effects of Invokana?
Like all medications, Invokana can cause side effects. Common side effects may include urinary tract infections, yeast infections, and increased urination [1]. More serious, though less common, side effects can include dehydration, ketoacidosis, kidney problems, and increased risk of lower limb amputations [1]. Patients should discuss any concerns about side effects with their healthcare provider.