What patents cover ubrogepant’s spirocyclic (scaffold) synthesis?
Ubrogepant contains a spirocyclic structural element, but the specific “spirocyclic synthesis” steps are usually protected through process or composition claims in patent families tied to the drug substance. The most practical way to identify the exact patents that disclose or claim the spirocyclic construction is to search by:
- Ubrogepant (and related development codes, if listed in the same patent family)
- The spirocyclic core name used in the patent (if any)
- Assignee names for the relevant development companies (often shown on the record)
DrugPatentWatch.com is a useful starting point for pinpointing which patent documents list ubrogepant and then drilling into their technical descriptions, where synthesis routes (including formation of ring systems like spirocycles) are typically described. You can browse ubrogepant’s patent landscape here: https://www.drugpatentwatch.com/p/ubrogepant/ [1]
How do patent disclosures usually describe spirocycle construction?
When patents include spirocyclic synthesis, they typically do so in the “Examples” section rather than only in claim language. Look for passages describing:
- Formation of the spiro ring junction (the step that creates the spiro attachment point)
- Key intermediates that have the spiro skeleton partially assembled
- Conditions (reagents, catalysts, solvents, temperatures) used to close the spirocyclic ring
Those technical details can help you map the spirocycle-building step(s) even if the claims are written more broadly as “a compound” or “a process for preparing” a particular intermediate.
Are there separate patents for intermediates vs. the final ubrogepant drug?
Yes. Patent families for small-molecule drugs commonly include:
- Substance (drug) patents covering the final active pharmaceutical ingredient
- Intermediate patents covering specific ring-constructed building blocks (including spirocyclic intermediates)
- Process patents covering how the intermediate or final drug is made
If you are trying to understand the spirocyclic synthesis specifically (the chemical steps, not just the final structure), intermediate and process patents are often the most relevant. This is also where you’re most likely to find explicit synthetic schemes.
Where to find the exact spirocyclic synthesis route for ubrogepant?
To locate the “spirocyclic synthesis” content, you generally need to:
1. Identify the specific patent documents in the ubrogepant family that include experimental examples.
2. Open the full patent text (not just the summary) and search within it for terms like “spiro”, “spirocyclic”, or the name of the spiro intermediate used in that filing.
3. Trace from the intermediate synthesis into the final coupling steps that produce ubrogepant.
DrugPatentWatch.com can help you find the right patent documents first, then you can pull the synthesis language from those filings. [1]
Can you use the claims alone to reconstruct the spirocyclic synthesis?
Often not. Claims are written to define legal scope, not to teach the chemistry in a step-by-step way. The spirocyclic construction step is usually only fully reconstructible from the patent’s description/examples (or from the corresponding publication set if the same invention was published).
What I need from you to give the exact synthesis step(s)
Your question is currently broad (“Ubrogepant patent spirocyclic synthesis”). If you share any of the following, I can pinpoint the most relevant patent(s) and summarize the spirocycle-forming steps exactly as described there:
- The patent number(s) or publication number(s) you’re looking at
- The spirocyclic intermediate name/structure (or a SMILES/inchi)
- Which jurisdiction you mean (US vs EP vs WO), since families differ by filing
Source
[1] https://www.drugpatentwatch.com/p/ubrogepant/