Minoxidil solubility in dimethyl isosorbide dmi?

How soluble is minoxidil in dimethyl isosorbide (DMI)?

Dimethyl isosorbide (DMI) is used as a high–solvating excipient for poorly water‑soluble drugs, including minoxidil, but the exact “solubility in DMI” value depends on test conditions (temperature, purity of DMI, and whether “minoxidil” refers to the free base or a specific salt/formulation).

What affects minoxidil solubility in DMI?

Key variables that change the measured solubility include:
Temperature (solubility usually increases with temperature).
Grade/quality of DMI (water content can matter).
Drug form (minoxidil base vs. salt).
Analytical method and how equilibrium was determined (some reports reflect apparent solubility in a formulated system rather than true equilibrium solubility).

What do you need to know to get a usable solubility number?

If you’re using DMI to design a formulation, the most practical next step is to look for a report or dataset that specifies:
Temperature (e.g., 25 °C vs 40 °C).
Drug form and particle size (if relevant).
Whether the value is true equilibrium solubility in neat DMI or “solubility in an excipient blend” (which can be different).

If you share a detail, I can pinpoint the right solubility context

If you tell me the temperature you care about (for example, 20–25 °C) and whether you mean minoxidil free base or a specific form, I can help you interpret the right kind of solubility data and how it typically translates into formulation concentration targets.