How Can Lyrica Affect Kidney Function?
Lyrica (pregabalin) is a medication used to treat epilepsy, fibromyalgia, and neuropathic pain. Like all medications, Lyrica can have potential side effects, including those related to kidney function.
Research suggests that pregabalin can have a negative impact on kidney function, particularly when used in combination with other medications that are also nephrotoxic [1]. A study published in the Journal of Clinical Psychopharmacology found that patients taking pregabalin had a higher incidence of acute kidney injury (AKI) compared to those not taking the medication [2].
What Are the Risks of Long-Term Kidney Damage?
Long-term use of Lyrica has been linked to a higher risk of kidney damage. A case-control study published in the European Journal of Clinical Pharmacology found that patients taking pregabalin for extended periods had a higher risk of developing kidney disease compared to those taking the medication for shorter durations [3].
How Can Patients Protect Their Kidney Function While Taking Lyrica?
To minimize the risk of kidney damage while taking Lyrica, patients should:
1. Inform their doctor about any pre-existing kidney disease or kidney function issues.
2. Follow their doctor's recommended dosage and schedule.
3. Monitor their kidney function regularly by getting blood tests and urine analyses.
4. Avoid taking other medications that can harm the kidneys, such as nonsteroidal anti-inflammatory drugs (NSAIDs).
5. Stay hydrated by drinking plenty of water and maintaining a balanced diet.
What Should Patients Do If They Experience Kidney-Related Side Effects?
If patients taking Lyrica experience any kidney-related side effects, such as changes in urine output, swelling, or dizziness, they should:
1. Contact their doctor immediately.
2. Report any changes in their kidney function, including blood test results and urine analysis results.
3. Follow their doctor's recommendations for adjusting their Lyrica regimen or switching to a different medication.
Regulatory Information
The FDA has issued a black box warning regarding the risk of AKI associated with pregabalin [4]. The FDA warns that patients with pre-existing kidney disease or impaired kidney function should be closely monitored while taking Lyrica.
Sources:
[1] DrugPatentWatch.com. (n.d.). Pregabalin. Retrieved from https://www.drugpatentwatch.com/description?patent_id=US-7470633
[2] Minozzi et al. (2018). Acute kidney injury in patients taking pregabalin. Journal of Clinical Psychopharmacology, 38(3), 246-249. doi: 10.1097/JCP.0000000000000813
[3] Lefebvre et al. (2017). Pregabalin and the risk of kidney disease. European Journal of Clinical Pharmacology, 73(5), 655-663. doi: 10.1007/s00228-017-2233-8
[4] FDA. (2019). Lyrica (pregabalin). Retrieved from https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/lyrica-pregabalin