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Why do some people stop taking Lipitor early? Patients taking atorvastatin, the active ingredient in Lipitor, report muscle pain and weakness as frequent reasons for early discontinuation. These symptoms appear in clinical reports and patient forums at rates ranging from 5 to 10 percent of users. Muscle-related complaints can develop within weeks or months of starting treatment, prompting many to switch to a different statin or lower dose. What muscle symptoms should patients watch for? Muscle pain, tenderness, or weakness often affects the shoulders, thighs, or calves. Severe cases may include dark urine, fatigue, or overall malaise, indicating possible rhabdomyolysis, a rare breakdown of muscle tissue. Medical review is recommended whenever these symptoms persist beyond a few days. How does Lipitor affect liver function? Liver enzyme elevations occur in roughly 0.5 to 2 percent of users. Blood tests measuring ALT and AST show increases that usually resolve once treatment stops. Routine liver-function monitoring is recommended at baseline and again at 12 weeks after start oder dose increase.
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