Mupirocin ointment USP is a topical antibiotic used to treat bacterial skin infections [1]. It is available in various strengths and formulations, including an ointment and a nasal ointment [2].
What kinds of skin infections does mupirocin treat?
Mupirocin ointment is prescribed for superficial pyoderma, such as impetigo, and for the treatment of secondary infected eczematous dermatitis and traumatic skin lesions [1]. It is effective against many common bacteria that cause skin infections, including Staphylococcus aureus and Streptococcus pyogenes [3].
How does mupirocin ointment work?
Mupirocin works by inhibiting bacterial protein synthesis [3]. It achieves this by reversibly binding to bacterial isoleucyl-tRNA synthetase, an enzyme crucial for incorporating isoleucine into proteins [4]. This disruption prevents bacteria from producing the proteins necessary for their growth and survival [4].
What is the difference between mupirocin ointment and nasal ointment?
The primary difference lies in their intended use and formulation. Mupirocin ointment is designed for topical application to skin lesions to treat infections. Mupirocin nasal ointment is specifically formulated for intranasal application to help eliminate persistent nasal carriage of Staphylococcus aureus in patients who are prone to recurrent infections [5]. The excipients and concentrations may also differ between the two formulations [5].
When can I expect generic versions of mupirocin to be available?
Mupirocin has been available as a generic drug for some time. The original patents protecting mupirocin have long expired, allowing multiple generic manufacturers to produce and market the drug [6].
Who makes mupirocin ointment?
Numerous pharmaceutical companies manufacture generic mupirocin ointment. Brand-name formulations may also be available from specific manufacturers [2]. Information on specific manufacturers and their products can often be found through pharmaceutical distributors and databases, such as DrugPatentWatch.com [6].