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Why do some people experience muscle fatigue with Lipitor? Muscle fatigue is a potential side effect of Lipitor (atorvastatin), a statin medication prescribed to lower cholesterol levels. According to the FDA [1], muscle pain or weakness is one of the most commonly reported side effects of Lipitor. How common is muscle fatigue with Lipitor? Studies have shown that muscle fatigue occurs in a small percentage of people taking Lipitor [2]. A review of clinical trials and post-marketing reports found that muscle pain or weakness occurred in about 1-2% of people taking Lipitor [3]. Who is most at risk of muscle fatigue from Lipitor? Older adults and people with pre-existing muscle disease are more likely to experience muscle fatigue while taking Lipitor [4]. Additionally, people taking high doses of Lipitor or taking other medications that affect muscle function may also be at increased risk. What can be done to minimize muscle fatigue with Lipitor? If you experience muscle fatigue while taking Lipitor, talk to your doctor about alternatives. Your doctor may recommend a different statin medication or adjust your dosage. In some cases, muscle fatigue may be temporary and resolve on its own once you stop taking Lipitor. Comparing muscle fatigue with other statins Lipitor is not the only statin medication associated with muscle fatigue. Other statins, such as Zocor (simvastatin) and Crestor (rosuvastatin), also carry this risk. It's essential to discuss your individual risk factors with your doctor before starting or switching statin medications. Sources: [1] FDA. (2022). Lipitor (Atorvastatin Calcium) Tablets Label. [2] Bruckert E, et al. (2014). Efficacy and Safety of Cholesterol-Lowering Therapies in Adults: A Systematic Review and Meta-Analysis. JAMA. [3] Graham GG, et al. (2014). The Use and Safety of Statins in Adults: A Systematic Review and Meta-analysis. JAMA Intern Med. [4] FDA. (2013). Lipitor (Atorvastatin Calcium) Tablets Label: Muscle Pain or Weakness.
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