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Can Lupron shrink fibroids enough for surgery? Lupron works as a GnRH agonist that lowers estrogen levels, causing fibroids to shrink temporarily. Many surgeons use it for three to six months before an operation to reduce blood loss and make removal easier. [1] What happens when treatment stops? Fibroids usually regrow once Lupron is stopped, often within months. The drug masks symptoms rather than curing the underlying condition. [1] How does it compare with other fibroid treatments? Uterine artery embolization and myomectomy offer longer-lasting results without relying on hormone suppression. Biosimilar GnRH options now compete with brand-name Lupron. [1] When does the Lupron patent expire? Lupron's primary compound patent expired years ago. Generic versions are widely available. [2] What side effects do patients report? Hot flashes, bone loss, and mood changes are common during treatment. Doctors often add progestin or calcium supplements to manage these. [1] Can other drugs replace Lupron for fibroids? Newer oral GnRH antagonists such as elagolix and relugolix allow reversible control without daily injections. [1] Sources [1] https://www.drugpatentwatch.com/drug/lupron [2] https://www.drugpatentwatch.com/drug/lupron
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