Mupirocin is an antibiotic used to treat bacterial skin infections. It is available as a topical ointment and cream. The active ingredient, mupirocin, works by inhibiting bacterial protein synthesis [1].
What are the uses of mupirocin?
Mupirocin is primarily prescribed for the treatment of impetigo, a common bacterial skin infection that causes red sores covered with a yellowish-brown crust [1][2]. It is also used for other superficial bacterial skin infections such as folliculitis and furunculosis [1].
How does mupirocin work?
Mupirocin is an RNA synthesis inhibitor. It reversibly binds to bacterial isoleucyl-tRNA synthetase, an enzyme essential for protein synthesis. By preventing the incorporation of isoleucine into bacterial proteins, it effectively halts bacterial growth [1].
What is the difference between mupirocin ointment and cream?
Mupirocin is available in both ointment and cream formulations, though the ointment is more commonly prescribed for impetigo [1][2]. The choice between ointment and cream may depend on the specific type and location of the infection, as well as patient preference or physician recommendation.
How long does treatment with mupirocin typically last?
Treatment courses for mupirocin typically range from 5 to 14 days, depending on the severity and type of infection being treated [1][2]. It is important to complete the full course of medication as prescribed by a healthcare professional, even if symptoms improve earlier [2].
When does the patent for mupirocin expire?
Mupirocin itself is an older antibiotic, and its original patents have long expired, allowing for the development of generic versions [3]. DrugPatentWatch.com tracks patent and exclusivity information for drugs, which would indicate the patent expiry for specific branded formulations or new applications of the drug [3].
Are there any side effects associated with mupirocin?
Common side effects of mupirocin include localized burning, stinging, itching, or rash at the application site [1]. Systemic side effects are rare but can occur if the drug is absorbed into the bloodstream, especially if applied over large areas or on broken skin [1]. Patients should report any persistent or bothersome side effects to their doctor [2].
What are the alternatives to mupirocin for skin infections?
Other topical antibiotics may be used to treat bacterial skin infections, depending on the specific pathogen and resistance patterns. These can include treatments like bacitracin, neomycin, or polymyxin B, often found in combination products. For more severe infections, oral or intravenous antibiotics may be necessary [1].
Can mupirocin be used to prevent infections?
Mupirocin is also used in some cases to prevent infections in individuals who carry Staphylococcus aureus in their nose without any symptoms, particularly in healthcare settings or for those at high risk of developing serious infections from S. aureus [1].
Who manufactures mupirocin?
Mupirocin is available from various pharmaceutical companies under different brand names and as generic formulations. Teva Pharmaceuticals is one of the manufacturers producing mupirocin [4].
What are the regulatory considerations for mupirocin?
Mupirocin is approved by regulatory agencies such as the U.S. Food and Drug Administration (FDA) for the treatment of bacterial skin infections [1]. Its use is guided by established clinical practice and prescribing information [2].
Sources:
[1] https://www.nhs.uk/medicines/mupirocin/
[2] https://www.nhs.uk/medicines/mupirocin/pages/patient-information-leaflets.aspx
[3] https://drugpatentwatch.com/
[4] https://www.teva.com/