Can I take Advil (ibuprofen) while I’m on amoxicillin?
In most cases, yes. Advil (ibuprofen) and amoxicillin are commonly used together, and there is no well-known direct interaction between the two that makes Advil unsafe while you’re taking amoxicillin.
What should I watch for if I take them together?
Even without an interaction, both medicines can cause side effects:
- Amoxicillin can cause stomach upset and diarrhea. If you get significant diarrhea, worsening abdominal pain, or blood/mucus in stool, call a clinician.
- Ibuprofen can irritate the stomach and, in some people, increase bleeding risk or affect kidneys—especially if you’re dehydrated or you take other medicines that affect bleeding.
If you have kidney disease, a history of stomach ulcers/bleeding, or you’re on blood thinners, it’s safer to ask a pharmacist or clinician before using ibuprofen.
Are there times when I should avoid Advil instead?
Consider avoiding Advil and using another approach (or asking your clinician) if you:
- Have a stomach ulcer or prior GI bleeding
- Have kidney problems or are significantly dehydrated
- Are taking blood thinners (for example, warfarin) or other NSAIDs
- Are told to avoid NSAIDs for another reason
For fever and pain, acetaminophen (Tylenol) is often the go-to alternative for people who need to avoid NSAIDs, but follow the label directions and any advice from your clinician.
When should I contact a doctor urgently?
Get medical care promptly if you develop signs of a serious allergic reaction to amoxicillin, such as hives, face/lip/tongue swelling, trouble breathing, or severe rash. Also seek urgent care if pain/fever is worsening instead of improving after starting antibiotics, or if you get severe diarrhea.
Source
No source was provided for this medication-interaction question.