What is activella?

Activella is a prescription hormone replacement therapy. It combines estradiol (a form of estrogen) with norethindrone (a progestin).

- What it’s used for: help treat menopausal symptoms such as hot flashes and night sweats, and, in women with a uterus, to protect the lining of the uterus from estrogen-related overgrowth. It may also be used to help prevent osteoporosis in some cases. It is not for use in pregnancy.

- How it’s taken: as an oral tablet, taken once daily exactly as prescribed. The exact strength and dosing schedule depend on the product your doctor prescribes.

- Common side effects: breast tenderness or swelling, nausea, headaches, mood changes, and spotting or breakthrough bleeding.

- Important risks and warnings: there is an increased risk of blood clots, stroke, heart attack, and certain cancers with estrogen-containing therapies. These drugs should not be used in people with certain conditions (eg, pregnancy, active or history of blood clots, estrogen-sensitive cancers, unexplained vaginal bleeding, liver disease, etc.).

If you’re considering Activella or have questions about whether it’s right for you, talk to your doctor or pharmacist. I can provide more details on dosing, side effects, or interactions if you’d like.