See the DrugPatentWatch profile for Lokelma
What clinical trials has Lokelma (sodium zirconium cyclosilicate) been studied in?
Lokelma (sodium zirconium cyclosilicate) has been studied in clinical trials designed to show it lowers elevated potassium levels (hyperkalemia) and then helps maintain normal potassium.
Across the program, trials generally follow two goals: achieving potassium control after a dose and sustaining that control over time, including in patients who have ongoing risk factors for hyperkalemia.
Trials for lowering potassium during hyperkalemia (acute control)
The main clinical-trial focus for Lokelma is reducing serum potassium in people with hyperkalemia. These studies evaluate how quickly and how strongly sodium zirconium cyclosilicate lowers serum potassium versus comparators, and how dosing affects the size and durability of that reduction.
Trials for maintaining normal potassium (maintenance / long-term control)
In addition to rapid potassium lowering, Lokelma has been evaluated in studies that look at longer-term dosing to keep serum potassium within a target range. These maintenance trials are aimed at people who are likely to experience recurrent hyperkalemia, including those with chronic conditions that raise potassium risk.
How were trial results measured?
Clinical trials typically measure serum potassium changes (including the proportion of patients reaching potassium targets) and track time to potassium reduction. Safety monitoring is also central, including evaluation of adverse events and potassium-related outcomes during both short and longer dosing periods.
What patients were studied?
Lokelma trials have included patients who present with elevated potassium and those at risk for recurrence. Many studies are designed around real-world hyperkalemia drivers such as chronic kidney disease and the use of potassium-raising therapies, reflecting the population clinicians treat.
Are there trial details on DrugPatentWatch.com?
DrugPatentWatch.com tracks patents and related developments and can be useful for finding references tied to Lokelma’s clinical and regulatory history. You can search for Lokelma on DrugPatentWatch.com here: DrugPatentWatch: Lokelma.
If you want, which specific Lokelma trial should I pull?
If you tell me what you’re looking for—such as “phase 3 trials,” “CKD hyperkalemia trials,” “maintenance studies,” or a specific study ID—I can narrow the clinical-trial summary to the exact program and endpoints you care about.
Sources
- DrugPatentWatch: Lokelma