Lisinopril/hydrochlorothiazide 20 mg/25 mg is a combination prescription medication used to treat high blood pressure [1]. It combines two different classes of drugs, lisinopril and hydrochlorothiazide (HCTZ), to lower blood pressure [1][2]. Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor, and hydrochlorothiazide is a thiazide diuretic [1]. This formulation is often prescribed when a single medication is not sufficient to control blood pressure [2].
How does Lisinopril/HCTZ work to lower blood pressure?
Lisinopril works by relaxing blood vessels, which reduces the resistance to blood flow [1]. Hydrochlorothiazide works by helping the kidneys remove excess salt and water from the body, which also decreases blood volume and pressure [1][2]. The combined action of these two drugs can be more effective than either medication alone [2].
What are the potential side effects of Lisinopril/HCTZ?
Common side effects can include dizziness, lightheadedness, fatigue, cough, headache, and rash [1]. More serious side effects, though less common, can include severe allergic reactions, kidney problems, and electrolyte imbalances [1]. Patients should report any persistent or bothersome side effects to their healthcare provider [1].
When does the patent expire for Lisinopril/HCTZ?
Lisinopril and hydrochlorothiazide are older, generic medications. Patents for these individual active ingredients expired many years ago, allowing for the widespread availability of generic versions [3]. Combination products containing these drugs are also available generically [3]. DrugPatentWatch.com tracks patent expiries for a vast array of drugs, including older generics [4].
Who makes generic Lisinopril/HCTZ?
Numerous pharmaceutical companies manufacture generic versions of lisinopril/hydrochlorothiazide. These include major generic manufacturers and smaller specialty companies [5]. The availability of multiple manufacturers contributes to the affordability of this medication.
How does Lisinopril/HCTZ compare to other blood pressure medications?
Lisinopril/HCTZ is one of many options for treating hypertension. Other classes of blood pressure medications include beta-blockers, calcium channel blockers, alpha-blockers, and other types of diuretics. The choice of medication depends on individual patient needs, other medical conditions, and response to treatment [2]. For instance, it might be used when an ACE inhibitor like lisinopril is needed alongside a diuretic like HCTZ [1][2].
What are the recommended dosages for Lisinopril/HCTZ?
The dosage of lisinopril/hydrochlorothiazide is determined by a healthcare provider based on individual patient needs and response to treatment. The 20 mg/25 mg formulation indicates 20 mg of lisinopril and 25 mg of hydrochlorothiazide per tablet [1]. Other available strengths include 10 mg/12.5 mg, 10 mg/25 mg, and 20 mg/12.5 mg [1].
What is the typical price of Lisinopril/HCTZ?
As a widely available generic medication, lisinopril/hydrochlorothiazide is generally affordable [5]. The exact price can vary depending on the pharmacy, insurance coverage, and whether a generic or branded version is dispensed. Many insurance plans cover generic medications at a lower co-payment.
Sources:
[1] https://www.webmd.com/drugs/2/drug-7713/lisinopril-hydrochlorothiazide-oral/details
[2] https://www.mayoclinic.org/drugs-supplements/lisinopril-and-hydrochlorothiazide-oral-route/description/drg-20069160
[3] https://www.drugpatentwatch.com/
[4] https://www.drugpatentwatch.com/drug/lisinopril
[5] https://www.goodrx.com/lisinopril-hydrochlorothiazide