Does Rinvoq (upadacitinib) cause constipation?
Yes. Constipation is a known side effect of Rinvoq (upadacitinib). It is reported as part of the drug’s adverse reactions information [1].
How common is constipation with Rinvoq?
Constipation is listed among Rinvoq’s side effects [1]. The exact frequency (for example, “common” vs. “uncommon” vs. “rare”) depends on the product’s prescribing information and specific study data, but it is recognized as an adverse reaction.
What should you do if you get constipation while taking Rinvoq?
If constipation starts after beginning Rinvoq, it’s reasonable to manage it with standard constipation measures (like increasing fluids and fiber, when appropriate). Contact a clinician promptly if symptoms are significant or persistent, because severe constipation can sometimes signal a more serious intestinal problem.
When is constipation a red flag?
Seek urgent medical care if constipation comes with warning signs such as severe or worsening abdominal pain, vomiting, a swollen belly, fever, blood in the stool, or inability to pass gas—these can indicate a bowel obstruction or another serious issue. Because Rinvoq affects the immune system, report GI symptoms to your prescriber rather than waiting it out.
Does constipation look different from other GI side effects on Rinvoq?
Rinvoq can cause multiple gastrointestinal symptoms, including diarrhea and abdominal discomfort, and constipation can also occur [1]. If your symptoms change quickly or are severe, clinicians may want to rule out other causes.
Can constipation be prevented or reduced?
Prevention depends on your baseline risk (history of constipation, diet, hydration, other medications). In general, staying hydrated and maintaining adequate fiber can help reduce constipation risk, but the best plan is individualized based on your other meds and health conditions.
Is constipation more likely with other medications?
It can be. Constipation often worsens when people take other drugs that slow the gut (for example, some pain medicines like opioids, certain antihistamines, and some antidepressants). If you started Rinvoq around the same time as another medication, mention both to your clinician.
What alternatives exist if constipation becomes a problem?
If constipation is persistent or troublesome, your clinician may adjust your supportive care or consider changing treatment. The decision depends on how severe the constipation is and why you’re taking Rinvoq (for example, inflammatory conditions).
Sources
[1] https://www.rxlist.com/rinvoq-side-effects-pro.htm