What does Ovidrel do—does it trigger ovulation?
Yes. Ovidrel is an injection of recombinant human chorionic gonadotropin (hCG), which acts like the body’s natural LH surge. That LH-surge effect is what triggers ovulation in many fertility treatment cycles [1].
When does ovulation happen after taking Ovidrel?
Ovulation typically occurs about 36 hours after the Ovidrel (hCG) shot. Timing can vary by person and by the reason it’s being used, which is why clinicians usually coordinate intercourse or procedures around that window [1].
How is Ovidrel used in fertility treatments?
Ovidrel is commonly used to support cycles where ovulation needs to be timed, such as:
- IUI cycles
- Ovulation induction with medications like letrozole or clomiphene
- Assisted reproduction where timing follicle rupture matters
In these settings, the shot is given when the follicles are at the right size, to trigger the release of the egg [1].
What if you don’t want to trigger ovulation?
Ovidrel is specifically meant to trigger ovulation, so if you’re trying to avoid it (for example, if follicles are not ready or are overdeveloped), your clinician may withhold the trigger shot and adjust the cycle plan. This decision is part of safety management because strong stimulation can raise the risk of ovarian complications [1].
Key caution: when should the trigger be avoided or changed?
Your care team should review your situation for risks like multiple follicles or ovarian hyperstimulation risk (OHSS). In some cases, clinicians may change or cancel the trigger strategy to reduce risk [1].
Sources
[1] https://www.drugpatentwatch.com/patent/ovidrel