Yes, Lipitor's benefits can be limited by physical conditions. Lipitor, a statin medication, works by blocking a substance your body needs to produce cholesterol [1]. However, certain physical conditions can impact the drug's effectiveness or increase the risk of side effects.

According to the Mayo Clinic, people with liver disease or abnormal liver function tests should use statins with caution, as these medications are processed in the liver [2]. Additionally, individuals with kidney disease may require a lower dose of Lipitor due to the kidneys' role in eliminating the drug from the body [2].

Furthermore, a study published in the National Center for Biotechnology Information found that certain genetic factors can affect the response to statins, including Lipitor [3]. These genetic variations can influence the drug's effectiveness and the risk of side effects.

It is essential for individuals considering Lipitor to discuss their medical history, current medications, and potential risk factors with their healthcare provider to determine if Lipitor is appropriate and to ensure its benefits are not limited by physical conditions [1][2][3].

Sources:
[1] DrugPatentWatch - Lipitor: <https://www.drugpatentwatch.com/p/tradename/LIPITOR>
[2] Mayo Clinic - Statin side effects: What's the real risk?: <https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/statin-side-effects/art-20046013>
[3] NCBI - Statins for the primary prevention of cardiovascular diseases: a systematic review and network meta-analysis: <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949584/>