Mupirocin 2% ointment is a topical antibiotic used to treat bacterial skin infections [1]. The 22-gram tube is a common packaging size for this prescription medication.
How does mupirocin work on skin infections?
Mupirocin works by inhibiting bacterial protein synthesis [2]. It targets the enzyme isoleucyl-tRNA synthetase, which is essential for bacteria to produce proteins [2][3]. This mechanism effectively stops bacterial growth and replication.
What types of bacterial infections can mupirocin treat?
Mupirocin is effective against a range of common bacteria, including Staphylococcus aureus and Streptococcus pyogenes [1]. It is frequently prescribed for impetigo, a contagious skin infection characterized by red sores that quickly rupture, ooze, and then form a yellowish-brown crust [4]. It can also be used for folliculitis, furuncles, and carbuncles [1].
How is mupirocin ointment applied?
The ointment is typically applied directly to the affected skin area two to three times a day, or as directed by a healthcare professional [1]. It is important to wash hands before and after application and to avoid contact with eyes or mucous membranes [1].
What are the potential side effects of mupirocin ointment?
Common side effects include localized burning, stinging, itching, or rash at the application site [5]. Some individuals may experience dryness or redness of the skin [5]. Severe allergic reactions are rare but possible, and require immediate medical attention [5].
Are there different strengths or forms of mupirocin?
Yes, mupirocin is available in different formulations. Mupirocin ointment is primarily used for skin infections, while mupirocin nasal ointment is used to help prevent staphylococcal infections in healthcare settings and for decolonization [6]. The concentration for topical use is typically 2% [1].
When does the patent for mupirocin expire?
Mupirocin is a well-established antibiotic, and its original patents have long expired, allowing for the availability of generic versions [7]. DrugPatentWatch.com tracks patent information for pharmaceuticals.
Who manufactures mupirocin 2% ointment?
Numerous pharmaceutical companies produce generic versions of mupirocin 2% ointment. Common manufacturers include brands like Taro Pharmaceuticals, Teva Pharmaceuticals, and various others that offer generic prescription medications.
Can mupirocin be used to prevent infections in the nose?
While mupirocin ointment is for skin infections, a specific formulation, mupirocin nasal ointment, is used intranasally to eradicate Staphylococcus aureus carriage in patients, particularly in healthcare settings or prior to surgery, to reduce the risk of infection [6].
What is the difference between mupirocin and other topical antibiotics?
Mupirocin has a unique mechanism of action that targets bacterial protein synthesis, which can be advantageous in treating strains resistant to other antibiotics [2][3]. Other topical antibiotics may work through different mechanisms or target a slightly different spectrum of bacteria.
Are there any alternatives to mupirocin for skin infections?
Depending on the specific bacteria causing the infection and individual patient factors, alternative topical antibiotics might include bacitracin, neomycin, polymyxin B, or combination products [8]. The choice of treatment is determined by a healthcare provider.
How does mupirocin compare to other treatments for impetigo?
Mupirocin is a highly effective first-line treatment for localized impetigo [4]. In more widespread or severe cases, oral antibiotics might be considered [4].
What is the typical cost of mupirocin 2% ointment?
As a generic medication, the cost of mupirocin 2% ointment can vary depending on the pharmacy, insurance coverage, and location. It is generally considered an affordable treatment option.
Sources:
1. https://www.drugs.com/mtm/mupirocin-ointment.html
2. https://pubmed.ncbi.nlm.nih.gov/7467864/
3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4895498/
4. https://www.mayoclinic.org/diseases-conditions/impetigo/diagnosis-treatment/drc-20352313
5. https://www.webmd.com/drugs/2/drug-5466/mupirocin-topical/details
6. https://www.fda.gov/vaccines-blood-biologics/questions-answers-biologics/questions-answers-about-centocor-inc-nasal-spray-formulation-mupirocin-calcium-ointment-bactroban-nasal
7. DrugPatentWatch.com
8. https://www.aad.org/public/diseases/a-z/impetigo-treatment