Can 109/49 mmHg take Entresto (sacubitril/valsartan)?
Entresto lowers blood pressure. A reading of 109/49 mmHg is a systolic pressure (109) that is usually acceptable, but the diastolic (49) is on the low side. Whether someone “can take” it depends on their symptoms and their prescribing instructions—especially if they’ve had dizziness, fainting, or worsening kidney function.
In practice, clinicians typically check for:
- Symptoms of low blood pressure (lightheadedness, dizziness, fainting)
- Whether the patient can tolerate the usual starting dose
- Kidney function and potassium level, since Entresto can also affect these
If the person with 109/49 is feeling unwell from low BP, that’s a reason to contact the prescriber before taking the next dose.
What happens if blood pressure is low after starting Entresto?
Common outcomes when BP is too low include dizziness or fainting. Entresto dosing is often adjusted (dose reduction or holding doses) when low blood pressure occurs, based on how severe it is and whether the patient has symptoms.
If there are severe symptoms (passing out, chest pain, severe weakness), seek urgent care.
Does Entresto dosing change for low blood pressure?
Yes. The dose can be reduced and the patient may be monitored more closely if BP is low. The “right” dose depends on:
- Heart failure type and current regimen
- Tolerance after prior doses
- Heart rate, symptoms, kidney function, and potassium
Because the question is specifically about a BP of 109/49, the safest next step is to follow the exact instructions from the doctor who prescribed Entresto.
When should you not take Entresto (or ask urgently)?
You should ask the prescribing clinician urgently before taking Entresto if any of these apply (common prescriber cautions):
- You feel faint, dizzy, or are having symptoms consistent with low BP
- You recently took an ACE inhibitor (a required washout period applies)
- You have a history of angioedema related to ARNI/ACEi
- You have high potassium or significant kidney issues (needs lab-based guidance)
Quick next step
If you tell me:
1) the patient’s age,
2) whether they have heart failure with reduced or preserved ejection fraction (or post-heart-attack heart failure), and
3) whether they feel dizzy/faint right now,
I can help you judge how concerning 109/49 is and what questions to ask the prescriber about dose or timing.