Yes, there are specific groups who should avoid long-term aspirin use. According to the American Heart Association (AHA) [1], aspirin therapy is recommended for people at high risk of a heart attack or stroke. However, long-term use of aspirin can have serious side effects, especially in certain groups.

The Food and Drug Administration (FDA) advises against the regular use of aspirin for prevention of heart attacks and strokes in people who have not already been diagnosed with cardiovascular disease or who have not had a stroke [2].

The following groups should avoid long-term aspirin use:

1. People with a high risk of gastrointestinal bleeding: Aspirin can increase the risk of stomach ulcers and bleeding in the digestive tract [1].

2. People with liver or kidney disease: Aspirin can worsen these conditions [1].

3. People with an allergy to aspirin: Aspirin can cause an allergic reaction, including hives, swelling, and difficulty breathing [1].

4. People taking other medications that increase the risk of bleeding: Aspirin can interact with other medications, such as blood thinners, nonsteroidal anti-inflammatory drugs (NSAIDs), and selective serotonin reuptake inhibitors (SSRIs), increasing the risk of bleeding [1].

5. Children and teenagers: Aspirin should not be given to children and teenagers with fever or flu-like symptoms, as it can increase the risk of Reye's syndrome, a rare but potentially fatal condition [1].

It is important to consult with a healthcare provider before starting or stopping aspirin therapy, as the benefits and risks of long-term aspirin use vary for each individual.

Sources:

[1] American Heart Association. (2021). Aspirin and Heart Disease, Stroke, and Cardiovascular Disease. <https://www.heart.org/en/health-topics/heart-attack/treatment-of-a-heart-attack/aspirin-and-heart-disease-stroke-and-cardiovascular-disease>.

[2] U.S. Food and Drug Administration. (2014). FDA Drug Safety Communication: FDA Strengthens Warning that NSAIDs Increase Risk of Heart Attack or Stroke. <https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-strengthens-warning-nonsteroidal-anti-inflammatory-drugs>.

[3] DrugPatentWatch.com. (n.d.). Aspirin. <https://www.drugpatentwatch.com/drugs/aspirin>.