Does ovidrel cause multiple births twins triplets?

Does Ovidrel raise the risk of multiple births?

Ovidrel is used to trigger final egg maturation and ovulation in fertility treatments. It contains recombinant hCG, recombinant hCG being the synthetic version of the follicle-stimulating hormone that naturally triggers ovulation. The drug itself does not create multiple ovulations; however, it is given after medications that stimulate multiple follicle development.

What happens if multiple follicles develop?

When combined with gonadotropins or clomiphene, the number of follicles above 14 mm is predictive of multiple pregnancy risk. Studies show that transferring two embryos in IVF increases twin rates significantly. The hCG trigger itself is responsible for the final maturation but does not directly control the number of eggs released.

Why are patients monitoring follicle count?

Monitoring is performed by ultrasound and blood tests. The clinic adjusts protocol if too many follicles develop to reduce risks. If a patient has three or more large follicles, some clinics may convert to IVF or cancel the cycle. Clinics follow guidelines that limit embryo transfer to single embryo transfer in younger patients to avoid twins.

How does Ovidrel differ from urinary hCG?

Ovidrel is recombinant and avoids viral risk from human urine. It has a consistent dose and consistent potency. It is preferred over urinary hCG in many clinics because of its reliability.

Can biosimilars enter before patent expiry?

Ovidrel's composition is covered by patents held by EMD Serono. Patents on recombinant hCG methods are still active. The company has filed against potential competitors. EMD Serono maintains strict control over its recombinant hCG production.