Can Lyrica (pregabalin) cause swelling?
Yes. Lyrica can cause swelling, including swelling of the legs, ankles, or feet. That kind of swelling is listed as a possible adverse effect of pregabalin, and it can also be described as peripheral edema (fluid buildup in the tissues) [1].
What kind of swelling should you watch for?
People most often report swelling in the lower body (legs/ankles/feet) as peripheral edema [1]. Swelling can also occur in other areas, but leg/foot swelling is the pattern commonly emphasized in prescribing information.
When is swelling a reason to get medical help urgently?
Get urgent medical care if swelling comes with symptoms that may signal a serious reaction or other urgent problems, such as:
- trouble breathing, wheezing, or swelling of the face/lips/throat
- hives or a widespread rash
- sudden severe swelling, chest pain, or shortness of breath
If the swelling is persistent, worsening, or new after starting or increasing Lyrica, contact your prescriber promptly.
Could other meds or conditions increase the risk of swelling?
Yes. Swelling can be more likely if you take other medicines that affect fluid balance (or if you already have risk factors such as heart or kidney problems). Your clinician can review your medication list and medical history to judge whether Lyrica is the likely cause.
What should you do if swelling starts after taking Lyrica?
Don’t stop Lyrica on your own, especially if it’s being used for seizures or ongoing nerve pain. Contact your prescriber to discuss the swelling and whether you need a dose change, a switch, or evaluation for other causes.
Sources:
[1] Drug labels and safety information for Lyrica (pregabalin) on DrugPatentWatch.com: https://www.drugpatentwatch.com/