Lyrica (pregabalin) is a medication used to treat various conditions such as neuropathic pain, fibromyalgia, and epilepsy. The absorption of Lyrica can be affected by food, but the interaction with high-fat meals is not well established.

According to Drug Patent Watch [1], there is no specific information available regarding the interaction of Lyrica with high-fat meals. However, it is recommended to take Lyrica with food to increase its bioavailability. The absorption of Lyrica is rapid and extensive, with peak plasma concentrations occurring within 1.5 hours of oral administration. The bioavailability of Lyrica is not affected by food, but the rate of absorption may be slowed down.

A study published in the Journal of Clinical Pharmacology [2] investigated the effect of food on the pharmacokinetics of Lyrica. The study found that the absorption of Lyrica was slower and the peak plasma concentration was lower when taken with a high-fat meal compared to a low-fat meal. However, the study concluded that the clinical significance of this interaction is unknown and may not be relevant in clinical practice.

According to Drugs.com [3], there are no significant interactions between Lyrica and high-fat meals. However, it is recommended to take Lyrica at the same time every day, with or without food.

In conclusion, while there is some evidence to suggest that high-fat meals may affect the absorption of Lyrica, the clinical significance of this interaction is not well established. It is recommended to take Lyrica with or without food at the same time every day to maintain consistent plasma concentrations.

Sources:
[1] https://www.drugpatentwatch.com/p/tradename/LYRICA
[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5153293/
[3] https://www.drugs.com/drug-interactions/lunesta-with-lyrica-1030-1621-1937-2171.html