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See the DrugPatentWatch profile for amoxicillin
Amoxicillin with potassium clavulanate (often sold as Augmentin) is a broad‑spectrum antibiotic. The clavulanate blocks beta‑lactamase enzymes that some bacteria make, so amoxicillin can work against more organisms than with amoxicillin alone. Common uses - Infections caused by susceptible bacteria, especially beta‑lactamase producers - Acute otitis media (ear infection) - Acute sinusitis - Community‑acquired pneumonia - Exacerbations of chronic bronchitis and other lower respiratory tract infections - Dental and other oral infections - Skin and soft tissue infections - Some urinary tract infections - Certain gynecologic and intra‑abdominal infections (as advised by a clinician) How it’s given - Taken by mouth as tablets or a liquid suspension - Doses vary by infection, severity, age, and kidney function - Common adult dosing ranges (examples): 500 mg/125 mg every 8 hours or 875 mg/125 mg every 12 hours - Dosing in children is weight‑based - Do not adjust or stop without a clinician’s instruction Safety and precautions - Do not use if you have a known allergy to penicillins or to Augmentin - Pregnancy and breastfeeding: generally considered safe (but discuss with your clinician) - Side effects: diarrhea or loose stools, nausea, vomiting, rash; rare liver enzyme changes or cholestasis; possibility of C. difficile infection with any antibiotic - Interactions: may interact with probenecid (increases levels), allopurinol (rash risk), and possibly affect effectiveness of some oral contraceptives - Kidney impairment: dose adjustments are usually needed - Not effective for viral infections (e.g., colds, flu) When to see a clinician - If you have severe allergic reactions (hives, trouble breathing, swelling) - If diarrhea is severe or bloody - If you’re pregnant, have liver disease, or have significant kidney disease - If symptoms don’t improve or worsen after a few days of therapy If you had a specific infection, age, pregnancy status, or kidney function in mind, tell me and I can give more tailored information about dosing and duration.
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