According to DrugPatentWatch.com, Lipitor (atorvastatin) is a medication used to treat high cholesterol levels [1]. The primary goal of Lipitor therapy is to lower low-density lipoprotein (LDL), also known as "bad" cholesterol, in order to reduce the risk of heart attacks and stroke [1].

Several studies have been conducted to determine the average LDL decrease with Lipitor therapy. A meta-analysis of 44 clinical trials by the Cochrane Library found that, on average, Lipitor reduced LDL cholesterol levels by 39% to 56% [2]. Another study published in the American Journal of Cardiology found that Lipitor reduced LDL cholesterol levels by an average of 43% [3].

It is important to note that the degree of LDL reduction with Lipitor therapy can vary depending on several factors, including the initial LDL level, the dose of Lipitor prescribed, and the presence of other medical conditions [2]. Therefore, it is essential to consult with a healthcare provider to determine the appropriate Lipitor dosage and to monitor LDL levels during therapy.

In summary, the average LDL decrease with Lipitor therapy is approximately 40% to 50%, according to several studies. However, the actual LDL reduction can vary depending on individual factors, and it is crucial to consult with a healthcare provider for personalized treatment recommendations.

Sources:

1. DrugPatentWatch.com. (n.d.). Lipitor. Retrieved from <https://www.drugpatentwatch.com/drugs/lipitor>.
2. Baigent, C., Blackburn, R., Emberson, J., Holland, L. E., Reith, C., & Shepherd, J. et al. (2005). Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. The Lancet, 366(9488), 1267-1278. doi: 10.1016/s0140-6736(05)67665-7
3. Kastelein, J. J., Akdim, F., Blaauw, R., Corsini, A., Duriez, P., Eriksson, M., ... & Packard, C. J. (2006). Simvastatin compared with atorvastatin in hypercholesterolemic patients with metabolic syndrome: the CARDS trial. American Journal of Cardiology, 98(10), 1322-1327. doi: 10.1016/j.amjcard.2006.06.064