Yes, certain supplements can interact with Lipitor (atorvastatin), a medication used to treat high cholesterol levels. These interactions can potentially decrease Lipitor's effectiveness or increase the risk of side effects. Here are some supplements known to interact with Lipitor:

1. Red Yeast Rice: This supplement contains monacolin K, which is the active ingredient in Lipitor. Combining the two can increase the risk of muscle damage (rhabdomyolysis) and liver damage [1].

2. Garlic: Garlic can also lower cholesterol levels. When taken with Lipitor, it might increase the risk of low blood sugar, bleeding, and kidney problems [1].

3. Coenzyme Q10 (CoQ10): Lipitor can decrease the levels of CoQ10 in the body, which is essential for cellular energy production. Taking CoQ10 supplements may help reduce muscle pain caused by Lipitor [2].

4. St. John's Wort: This herbal supplement can interact with various medications, including Lipitor, by reducing their effectiveness [1].

5. Vitamin E: High doses of vitamin E can increase the risk of bleeding, especially when taken with Lipitor [1].

6. Grapefruit Juice: While not a supplement, grapefruit juice can interact with Lipitor by increasing the amount of medication in the blood, potentially leading to adverse effects [1].

It is crucial to consult a healthcare provider before starting or continuing any supplements while taking Lipitor, as interactions can vary depending on individual factors.

Sources:
[1] Drugs.com. (n.d.). Atorvastatin Interactions. Retrieved from https://www.drugs.com/drug-interactions/atorvastatin,interactions.html
[2] DrugPatentWatch. (2021). Lipitor (Atorvastatin) Drug Interactions. Retrieved from https://www.drugpatentwatch.com/drugs/lipitor/interactions