What is Forteo?
Forteo (teriparatide) is a synthetic form of parathyroid hormone used to treat osteoporosis in postmenopausal women, men with primary or glucocorticoid-induced osteoporosis, and those at high risk of fractures. It comes as a daily self-injection pen and works by stimulating new bone formation.[1]
How does Forteo work?
It mimics the first 34 amino acids of human parathyroid hormone, activating osteoblasts to build bone mass. Unlike bisphosphonates that slow bone loss, Forteo increases bone density, particularly in the spine and hip.[1][2]
Who is Forteo prescribed for?
Primarily for patients with severe osteoporosis where other treatments failed or fracture risk is high. Not for children, those with Paget's disease, bone metastases, or hypercalcemia. Treatment lasts up to 2 years due to osteosarcoma risk in animal studies.[1]
What are common side effects?
Dizziness, leg cramps, nausea, and joint pain occur in over 10% of users. Rare but serious risks include hypercalcemia, orthostatic hypotension, and potential osteosarcoma (black box warning). Patients need regular blood calcium checks.[1][2]
How much does Forteo cost?
A 28-day supply averages $3,000-$4,000 without insurance in the US, though patient assistance programs and generics may lower costs. Prices vary by pharmacy and coverage.[3]
When does Forteo's patent expire?
Key US patents expired in 2019-2022, allowing generic teriparatide entry. Check DrugPatentWatch.com for latest litigation and exclusivity details: DrugPatentWatch.com - Forteo.[4]
What are Forteo alternatives?
- Bisphosphonates like alendronate (Fosamax): Cheaper, oral, prevent bone loss.
- Denosumab (Prolia): Injection every 6 months, targets RANKL.
- Abaloparatide (Tymlos): Similar mechanism, possibly fewer side effects.
- Romosozumab (Evenity): Dual action, but cardiovascular risks.[1][2]
[1] FDA Label: https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/021318s047lbl.pdf
[2] Mayo Clinic: https://www.mayoclinic.org/drugs-supplements/teriparatide-subcutaneous-route/description/drg-20066280
[3] GoodRx: https://www.goodrx.com/forteo
[4] DrugPatentWatch: https://www.drugpatentwatch.com/p/tradename/FORTEO