What side effects does Cosentyx (secukinumab) list, and is depression one of them?
Cosentyx (secukinumab) can cause common side effects such as infections (including upper respiratory infections), rash, and injection-site reactions, and it can also be associated with worsening or triggering certain infections. The available information provided here does not identify depression as a listed side effect for Cosentyx.
Are mood changes or depression connected to Cosentyx?
Patients and clinicians sometimes look for links between biologic therapies and changes in mood, but depression is not specifically identified as an adverse effect in the provided information. If someone taking Cosentyx develops new or worsening depressive symptoms, the safest next step is to report them promptly to a prescribing clinician so the cause can be evaluated and treated.
What should you do if depression happens while taking Cosentyx?
If depression symptoms appear after starting Cosentyx, contact the prescriber. They may check for:
- Infection-related complications (since biologics can increase infection risk)
- Other medications or underlying conditions that can affect mood
- Whether additional monitoring or a treatment change is needed
Seek urgent help immediately for suicidal thoughts or severe worsening mood symptoms.
Could Cosentyx indirectly affect mood through infections or other reactions?
Even when depression is not directly listed as a side effect, infections and systemic illness can affect sleep, energy, and overall mental health. Because Cosentyx can affect immune function, any significant infection during treatment should be assessed promptly, and mood symptoms should be discussed alongside physical symptoms.
When to ask your doctor about stopping or switching
Don’t stop Cosentyx on your own. Ask the prescriber about next steps if mood symptoms are:
- New and persistent
- Getting worse over days to weeks
- Accompanied by fever, severe fatigue, or signs of infection
Sources
No sources were provided in the prompt. If you share the specific Cosentyx label text (or a link you’re using), I can pinpoint whether depression appears as a listed adverse effect in that document.