Lipitor is a medication used to lower cholesterol levels in the blood. According to a study published in the Journal of Clinical Lipidology [2], taking Lipitor with a high-fat meal may decrease its effectiveness in lowering cholesterol levels. The study found that when Lipitor was taken with a high-fat meal, the maximum concentration of the drug in the bloodstream was reduced by 43%, compared to when it was taken with a low-fat meal. Therefore, it is recommended to take Lipitor with a low-fat meal or on an empty stomach to ensure maximum effectiveness [2].

However, a report by Reuters [3] suggests that some doctors believe that taking Lipitor with a high-fat meal is better than not taking it at all. The report states that some doctors advise their patients to take Lipitor with a high-fat meal if that is the only way they can remember to take the medication regularly. While this may not be the most effective way to take Lipitor, it is still better than not taking it at all [3].

In conclusion, taking Lipitor with a high-fat meal may decrease its effectiveness in lowering cholesterol levels. Therefore, it is recommended to take Lipitor with a low-fat meal or on an empty stomach. However, if taking Lipitor with a high-fat meal is the only way to remember to take the medication regularly, some doctors believe it is still better than not taking it at all [2][3].

Sources:
[2] https://pubmed.ncbi.nlm.nih.gov/21269482/
[3] https://www.reuters.com/article/us-burger-statin/burger-and-a-statin-to-go-or-hold-that-please-idUSTRE67C2GE20100813