Tricyclic antidepressants (TCAs) might affect the effectiveness of Advil by altering the way the body metabolizes ibuprofen, a key ingredient in Advil. Research suggests that TCAs can induce enzymes in the liver, such as cytochrome P450 2C9 (CYP2C9), which break down ibuprofen in the body ([1], [2]).

This increase in CYP2C9 enzyme activity can increase the rate at which ibuprofen is metabolized, potentially leading to reduced concentrations of ibuprofen in the body [2]. Consequently, taking TCAs and Advil together may reduce the effectiveness of Advil.

Additionally, TCAs can also affect the blood levels of ibuprofen by inhibiting certain enzymes responsible for metabolizing it, specifically cytochrome P450 3A4 (CYP3A4) [3].

It's essential to note that the interactions may vary depending on individual factors, such as the specific type of TCA being taken and the dosage of ibuprofen. If you're taking either TCAs or Advil, it's crucial to discuss this with your healthcare provider.

Sources:
[1] https://www.drugpatentwatch.com/drug/ibuprofen
[2] Drug Interactions: An Evidence-Based Approach to Problems of Drug Compatibility by Richard E. Roskoski, et al.
[3] https://www.drugbank.ca/drugs/DB01128