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How do OTC pain relievers affect Lipitor? Many common OTC pain relievers such as ibuprofen and naproxen can raise the risk of muscle damage when taken with Lipitor. Acetaminophen is usually a safer choice for occasional pain, but it still requires checking total daily dose limits. Which OTC supplements interfere with Lipitor? St. John's wort speeds up the breakdown of Lipitor and can reduce its cholesterol-lowering effect. Red yeast rice contains natural statin compounds that increase the chance of muscle pain or liver problems when combined with Lipitor. High-dose niacin and large amounts of grapefruit products can also raise blood levels of the drug. What happens if I drink grapefruit juice while on Lipitor? Even one 8-ounce glass of grapefruit juice can increase Lipitor levels enough to heighten side-effect risk. The effect can last up to 24 hours, so spacing the juice and the pill does not reliably prevent the interaction. When should I talk to a pharmacist about OTC choices? Before starting any new OTC medicine or supplement, bring a current list of all products to the pharmacist. They can quickly flag combinations that raise statin levels, affect liver enzymes, or reduce Lipitor's effectiveness.
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