What side effects have been reported with darolutamide?
Darolutamide is generally well tolerated, but side effects can occur. Commonly reported ones include fatigue, nausea, diarrhea, and falls, along with lab changes such as low red blood cells (anemia) and low white blood cells (neutropenia) [1]. Some patients also report decreased appetite and weight loss [1].
How severe are darolutamide side effects usually?
Most side effects are mild to moderate for many patients. Severe events are less common, but they can happen, including infections related to low white blood cell counts and complications from falls [1]. The exact risk depends on overall health, other medications, and prior cancer therapy.
What should patients watch for and report right away?
Seek medical care promptly for symptoms that could signal serious complications, especially if they include:
- Signs of infection (fever, chills, worsening weakness), which can relate to low white blood cells [1]
- Severe or persistent diarrhea or dehydration [1]
- Symptoms after a fall, such as head injury or new/worsening pain [1]
- Any signs of a more serious allergic reaction (rash with swelling, trouble breathing)
Does darolutamide interact with other drugs?
Darolutamide can interact with other medicines, which may increase side-effect risk or reduce effectiveness. Clinicians typically review the patient’s full medication list for potential interactions before starting treatment [1].
Where do these side effects come from?
These side effects are based on clinical trial safety reports for darolutamide in prostate cancer settings [1].
Sources
[1] https://www.accessdata.fda.gov/drugsatfda_docs/label/