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Most people do not have to take Advil (ibuprofen) with food, but taking it with food can make it easier on your stomach.
Ibuprofen can irritate the lining of the stomach and may increase the chance of stomach pain, heartburn, nausea, or bleeding—risk is higher when taken without food.
It’s generally better to take it with food (or after a meal) if you: - Have a history of stomach ulcers or GI bleeding - Get frequent heartburn or gastritis - Take other medicines that raise bleeding risk (for example, blood thinners or steroids)
A common approach is to take it with a meal or snack and a full glass of water. Avoid lying down right after taking it if it tends to cause heartburn.
Talk with a clinician or pharmacist before using ibuprofen if you have kidney disease, are pregnant (especially later pregnancy), take blood thinners, or have been told to avoid NSAIDs.
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