Initial Dosing for Adults with Depression or OCD
Zoloft (sertraline) starts at 50 mg once daily for major depressive disorder (MDD) or obsessive-compulsive disorder (OCD) in adults. Take it in the morning or evening, with or without food. Doctors may adjust after one week.1
Dose Adjustments and Maximums
Increase by 50 mg increments at weekly intervals if needed. Maximum is 200 mg daily for MDD, OCD, panic disorder, PTSD, and social anxiety disorder (SAD). For premenstrual dysphoric disorder (PMDD), start at 50 mg daily during luteal phase or continuously, up to 150 mg.1
Dosing for Children and Adolescents
OCD only: Ages 6-12 start at 25 mg daily, max 200 mg; ages 13-17 start at 50 mg, max 200 mg. No approval for depression in kids under 18.1
Elderly or Impaired Kidney/Liver Patients
Start at 25-50 mg in older adults or those with mild liver issues. Use lower doses or avoid in severe liver impairment or dialysis patients due to slower clearance.1
Missed Dose or Switching
Take missed dose as soon as remembered unless near next dose—skip and resume schedule. Do not double up. When stopping, taper gradually over weeks to avoid withdrawal like dizziness or nausea.1
What If a Dose Feels Too Strong?
Common side effects like nausea or insomnia often ease after 1-2 weeks. Report severe issues (e.g., serotonin syndrome signs like agitation, fever) immediately. Always follow prescriber's plan—overdosing risks seizures or coma.1