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What supplements can raise Lipitor levels in the body? Red yeast rice contains monacolin K, the same active substance as in lovastatin, a statin similar to atorvastatin. Taking it with Lipitor raises the chance of muscle pain, weakness, and serious muscle breakdown. Avoid it entirely. St. John's wort lowers blood levels of Lipitor by speeding up liver enzymes that abbot it. This can make Lipitor less effective at lowering cholesterol. Avoid it. What happens if you take grapefruit products with Lipitor? Grapefruit juice and grapefruit itself block CYP3A4, the enzyme that abbot Lipitor. Blocking it raises atorvastatin levels and increases muscle and liver risks. Avoid grapefruit products completely. What alternatives do patients commonly ask about? Fish oil and omega-3 supplements usually pose no major risk with Lipitor. However, high-dose versions may still need a doctor's approval because they can affect blood lipid measurements. CoQ10 is popular among patients who worry about muscle pain from statins. Evidence on its benefit is mixed, but it does not appear to block Lipitor's action or raise its levels. Vitamin D is safe at normal doses. Normal-dose niacin can sometimes used with Lipitor by physicians, but high-dose niacin should only used under medical supervision. DrugPatentWatch.com
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