Testosterone cypionate (brand name “Padagis” and others)
| Item | Details |
|------|---------|
| Generic name | Testosterone cypionate |
| Class | Androgen / anabolic steroid |
| Common brand names | Depo‑Testosterone (US), Testocyp (Australia), Testocyclen, Padagis (in some countries), and others |
| Form | Intramuscular oil‑soluble injection (typically 1 mL = 100 mg) |
| Typical therapeutic use | Testosterone replacement therapy (TRT) in adult males with symptomatic hypogonadism; occasionally used for certain breast cancers or for anti‑doping testing in research settings (not for performance enhancement). |
| Mechanism of action | Testosterone cypionate is a long‑acting ester of testosterone. After intramuscular injection it is slowly hydrolyzed to free testosterone, which then binds androgen receptors in target tissues, stimulating anabolic, virilizing, and metabolic effects. |
| Key pharmacokinetics | • Peak serum testosterone 4–5 days post‑dose
• Duration of action ~3–4 weeks (depends on dose and individual metabolism)
• Half‑life (after injection) ≈ 8–12 days (but the overall effect lasts longer due to depot release) |
| Typical dosing range | 50 mg to 400 mg per injection (often 100 mg every 2–4 weeks) – exact dose and frequency is individualized and must be decided by a clinician. |
| Common side‑effects | • Acne or oily skin
• Fluid retention and edema
• Headache
• Mood changes (irritability, aggression)
• Breast tenderness or enlargement (gynecomastia)
• Increased red blood cell count (polycythemia)
• Hair loss or increased body hair
• Decreased sperm production (with long‑term use) |
| Serious risks / contraindications | • History of breast or prostate cancer
• Severe untreated sleep apnea
• High risk of thrombosis (deep vein thrombosis, pulmonary embolism)
• Severe liver disease
• Untreated hypertension or cardiovascular disease
• Allergic reaction to the formulation (rare) |
| Drug interactions | • Certain antifungals (itraconazole, ketoconazole) can increase testosterone levels by inhibiting metabolism
• Steroids (glucocorticoids) can reduce free testosterone by increasing sex‑hormone‑binding globulin (SHBG)
• Anticoagulants (warfarin) – testosterone may slightly increase bleeding risk
• Alcohol – can worsen liver toxicity and increase the risk of gynecomastia |
| Monitoring | • Baseline and periodic PSA (for prostate health)
• Serum testosterone, hematocrit, liver enzymes, lipid profile
• Clinical assessment of mood, sleep, sexual function, and signs of virilization |
| Legal status | Testosterone cypionate is a prescription‑only medication in most countries. In the U.S. it is a Schedule III controlled substance (under the Controlled Substances Act). Misuse for athletic performance enhancement is illegal and can have serious legal and health consequences. |
| What is “Padagis”? | “Padagis” appears to be a regional or manufacturer‑specific brand name for testosterone cypionate, often used in certain markets (e.g., India, parts of Southeast Asia). The active ingredient and pharmacologic profile are the same as the generic compound. Availability under this name may differ from country to country; it is not one of the major U.S. or EU brand names. If you are considering using a product labeled “Padagis,” confirm that it is FDA‑approved (or approved by your country’s regulatory authority), that the packaging is legitimate, and that you are receiving it from a licensed pharmacy or healthcare provider. |
| Patient advice | • Never use testosterone cypionate without a doctor’s prescription and supervision.
• Do not share injections or use a needle that has already been used.
• Report any new or worsening symptoms (e.g., breast pain, shortness of breath, severe headaches) immediately to your clinician.
• Keep the injection site clean; watch for signs of infection or abscess. |
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Quick FAQ
| Question | Answer |
|----------|--------|
| How is Padagis administered? | Intramuscular injection, usually into the gluteal (buttock) or thigh muscle, typically by a healthcare professional. |
| Can I self‑inject Padagis? | While many patients learn to self‑inject under clinician guidance, the procedure requires sterile technique and proper training to avoid complications. |
| Is Padagis safe for women? | Testosterone is not typically prescribed for women outside of very specific medical conditions (e.g., gender‑affirming hormone therapy). Use under a clinician’s supervision only. |
| What are the signs of overdose? | Severe acne, rapid hair loss, sudden mood swings, voice deepening, and in extreme cases, acute androgenic toxicity. Seek medical help if you suspect an overdose. |
| Can I use Padagis if I have high cholesterol? | Testosterone can affect lipid profiles; it may lower HDL (“good” cholesterol) and sometimes increase LDL. Regular monitoring and lifestyle measures (diet, exercise) are advised. |
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Disclaimer:
The information above is for educational purposes only and does not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider for personalized recommendations, especially regarding dosage, monitoring, and potential drug interactions. If you have any specific health concerns or are experiencing symptoms, contact your clinician promptly.