Clemastine fumarate class ethanolamine antihistamine structure?

Q: Clemastine fumarate class ethanolamine antihistamine structure?

Clemastine fumarate – An H₁‑antagonist of the ethanolamine class (first‑generation, “sedating” antihistamine). 1. What it is Feature Details Drug class First‑generation antihistamine – 2‑ethanolamine derivative Mechanism Competitive blockade of histamine H₁ receptors → ↓ vasodilation, ↓ plasma leakage, ↓ itching Clinical use Allergic rhinitis, urticaria, pruritus, allergic conjunctivitis; sometimes used for vertigo or as a pre‑operative sedative Form Usually sold as the fumarate salt (protonated base + fumaric acid) to improve aqueous solubility and stability 2. Chemical identity Property Value Drug name Clemastine fumarate Free base Clemastine IUPAC name N,N‑dimethyl‑2‑[2‑chlorophenyl]‑2‑[4‑(2,4,4‑trimethyl‑3‑oxobutyl)phenyl]ethanolamine Molecular formula C₂₄H₃₂ClN₂O Molecular weight 378.82 g mol⁻¹ (free base) SMILES Clc1ccc(cc1)C(C(c2ccc(cc2)C(=O)C(C)(C)C)O)CN(C)C InChIKey YJYVYIYRGYQYOS‑NUPYVJYSSA‑N Tip: The SMILES string above can be pasted into a chemical structure viewer (e.g., PubChem, ChemDraw

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Accepted Answer

Clemastine fumarate
– An H₁‑antagonist of the ethanolamine class (first‑generation, “sedating” antihistamine).

1. What it is

Feature	Details
Drug class	First‑generation antihistamine – 2‑ethanolamine derivative
Mechanism	Competitive blockade of histamine H₁ receptors → ↓ vasodilation, ↓ plasma leakage, ↓ itching
Clinical use	Allergic rhinitis, urticaria, pruritus, allergic conjunctivitis; sometimes used for vertigo or as a pre‑operative sedative
Form	Usually sold as the fumarate salt (protonated base + fumaric acid) to improve aqueous solubility and stability

2. Chemical identity

Property	Value
Drug name	Clemastine fumarate
Free base	Clemastine
IUPAC name	N,N‑dimethyl‑2‑[2‑chlorophenyl]‑2‑[4‑(2,4,4‑trimethyl‑3‑oxobutyl)phenyl]ethanolamine
Molecular formula	C₂₄H₃₂ClN₂O
Molecular weight	378.82 g mol⁻¹ (free base)
SMILES	`Clc1ccc(cc1)C(C(c2ccc(cc2)C(=O)C(C)(C)C)O)CN(C)C`
InChIKey	YJYVYIYRGYQYOS‑NUPYVJYSSA‑N

Tip: The SMILES string above can be pasted into a chemical structure viewer (e.g., PubChem, ChemDraw

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Clemastine fumarate class ethanolamine antihistamine structure?

1. What it is

2. Chemical identity