What is chlorpromazine?
Chlorpromazine is a prescription antipsychotic medicine that was developed as an earlier treatment for severe mental health conditions, especially schizophrenia and other psychotic disorders. It belongs to the “first-generation” (typical) antipsychotics class.
What is it used for?
Clinicians have historically used chlorpromazine to treat psychosis (including schizophrenia). It has also been used in some settings for other symptoms and conditions where antipsychotic effects are helpful, depending on the patient and local prescribing guidance.
How does chlorpromazine work?
Chlorpromazine works mainly by affecting brain dopamine signaling, which helps reduce psychotic symptoms. Like other typical antipsychotics, it also has effects on other neurotransmitter systems, which contributes to both its benefits and side effects.
What side effects should people know about?
Common and important risks with typical antipsychotics like chlorpromazine can include sleepiness, dizziness, dry mouth, constipation, and low blood pressure when standing. It can also cause movement-related side effects (such as stiffness or restlessness) and increases the risk of a rare but serious condition called neuroleptic malignant syndrome (NMS). Patients are typically monitored for these effects.
Who should be careful using it?
People with certain cardiovascular problems (because it can affect blood pressure and heart rhythm), those with a history of severe medication reactions, and anyone taking interacting medications should discuss safety with a clinician. Because chlorpromazine can cause sedation, driving and other potentially risky activities may need caution.
Is chlorpromazine still prescribed today?
Yes. Even though newer antipsychotics are widely used, chlorpromazine remains in medical use in some places and for specific clinical situations where it is appropriate.
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