250 mcg ovidrel?

What is ovidrel, and how does it work?

Ovidrel, also known as recombinant human chorionic gonadotropin (rhCG), is a medication used to stimulate ovulation in women with polycystic ovary syndrome (PCOS) or other ovulation disorders [1]. It is available in a dosage of 250 micrograms (mcg) and is administered through injection.

How is ovidrel used in assisted reproductive technology (ART)?

In ART, ovidrel is often used in conjunction with fertility medications to stimulate ovulation and promote egg development. It is typically administered 34-35 hours after the administration of a trigger injection, such as lupron or ganirelix, to induce ovulation [2].

What are the side effects of ovidrel?

Common side effects of ovidrel include injection site pain, headache, and nausea [1]. More severe side effects, such as allergic reactions, deep vein thrombosis, and ovarian hyperstimulation syndrome (OHSS), are less common but can occur [3].

When should ovidrel not be used?

Ovidrel is contraindicated in women with uncontrolled thyroid or adrenal gland disorders, bleeding disorders, or a history of ovarian cancer [1]. Women with a history of ovarian torsion or ovarian cysts should also use ovidrel with caution.

How long does ovidrel's effect last?

The effects of ovidrel can last for several days, but the peak ovulation-inducing effect typically occurs 34-48 hours after administration [2].

What is the patent situation for ovidrel?

The recombinant human chorionic gonadotropin (rhCG) technology, including the formulation and method of use for ovidrel, is covered by a patent held by Merck Sharp & Dohme Corp. (MSD). However, the patent has expired in some countries, and generic versions of ovidrel are available [4].

Sources:

[1] https://www.merck.com/product/usi/ovidrel-250-ug-per-mL-for-intramuscular-injection.html (Ovidrel product page)

[2] https://www.merck.com/product/usi/ovidrel-ifn-2b-ifn-alpha-2b-for-intramuscular-injection.html (Ovidrel IFN product page)

[3] MedlinePlus. (2019). Ovidrel. Retrieved from https://medlineplus.gov/druginfo/meds/a601029

[4] DrugPatentWatch.com. (2023). Recombinant human chorionic gonadotropin (rhCG). Retrieved from https://www.drugpatentwatch.com/compound/recombinant-human-chorionic-gonadotropin-rhcg