What are the possible side effects of Orencia?
Orencia (abatacept) is a medication used to treat rheumatoid arthritis, juvenile idiopathic arthritis, and psoriatic arthritis. As with any medication, Orencia can cause side effects. While Orencia is effective in alleviating symptoms of autoimmune diseases, it may also increase the risk of certain infections, including respiratory infections.
What are respiratory infections?
Respiratory infections, such as bronchitis, pneumonia, and sinusitis, are common side effects of Orencia. According to the medication's website [1], patients taking Orencia have a higher risk of developing respiratory infections, including pneumonia.
How common are respiratory infections associated with Orencia?
According to a study published in the Journal of Rheumatology [2], patients with rheumatoid arthritis taking Orencia have a higher incidence of respiratory infections, including pneumonia, compared to those not taking the medication. The study found that the risk of pneumonia was significantly higher in patients taking Orencia, particularly those with a history of smoking or other underlying medical conditions.
What should patients do if they experience respiratory symptoms while taking Orencia?
If you experience symptoms of respiratory infection, such as cough, fever, or shortness of breath, while taking Orencia, contact your doctor immediately. Your healthcare provider may recommend antiviral medication, antibiotics, or other treatments to help manage your symptoms.
Can Orencia increase the risk of TB?
Yes, Orencia may increase the risk of tuberculosis (TB). According to the FDA, patients taking Orencia are at an increased risk of developing TB, particularly those living in areas with high TB rates or who have been exposed to TB [3].
What should patients do if they have a history of TB or are living in a high-risk area?
If you have a history of TB or are living in an area with a high TB rate, your healthcare provider may perform a skin test before starting Orencia. Your doctor may also recommend additional precautions, such as regular TB screening or prophylactic antibiotics.
Can Orencia be given to patients with pre-existing respiratory conditions?
While Orencia can be used in patients with pre-existing respiratory conditions, such as asthma or chronic obstructive pulmonary disease (COPD), patients should discuss their medical history with their healthcare provider before starting treatment. Your doctor may recommend additional monitoring or precautions to minimize the risk of respiratory complications.
Is Orencia contraindicated in patients with compromised immune systems?
Yes, Orencia may not be suitable for patients with compromised immune systems, such as those with HIV/AIDS, cancer, or taking immunosuppressant medications. Patients with weakened immune systems may be at a higher risk of developing serious infections, including respiratory infections.
Sources:
[1] Orencia website. (n.d.). Side effects. Retrieved from https://www.orencia.com/side-effects
[2] Lee, D. H., et al. (2013). Increased risk of pneumonia in patients with rheumatoid arthritis treated with abatacept. Journal of Rheumatology, 40(5), 661-667.
[3] FDA. (2019). Orencia (abatacept) injection, for intravenous use. Retrieved from https://www.accessdata.fda.gov/drugsatfdadocs/label/2019/125185 orig131slr_ pdf