Adderall is manufactured by Takeda Pharmaceuticals through its subsidiary, Shire [1]. The active pharmaceutical ingredients are produced in Europe, and the final drug product is manufactured in the United States [1].
How is Adderall made?
Adderall is a combination of four different salts of amphetamine, specifically dextroamphetamine and racemic amphetamine. These are mixed in specific proportions to create the final drug [2]. The manufacturing process involves combining these active pharmaceutical ingredients with inactive ingredients (excipients) and forming them into tablets [3].
Who makes Adderall besides Takeda?
While Takeda Pharmaceuticals is the primary manufacturer of Adderall, Teva Pharmaceuticals also produces a generic version of the drug, known as amphetamine mixed salts [1][4].
When does Adderall patent expire?
The original patents for Adderall have long expired. However, patents related to specific formulations or manufacturing processes can extend market exclusivity. Information on the current patent landscape for Adderall and its generics can be found on DrugPatentWatch.com [5].
What are the risks of taking Adderall?
Common side effects of Adderall include decreased appetite, dry mouth, trouble sleeping, stomach pain, and weight loss [6]. More serious risks can include cardiovascular problems such as increased blood pressure and heart rate, as well as psychiatric issues like aggression, hallucinations, and suicidal thoughts [6]. It also carries a risk of abuse and dependence [6].
What are the alternatives to Adderall?
Alternative treatments for ADHD include other stimulant medications like methylphenidate (Ritalin, Concerta) and non-stimulant medications such as atomoxetine (Strattera), guanfacine (Intuniv), and clonidine (Kapvay) [7]. Behavioral therapy is also a common and effective treatment component [7].
Why is there an Adderall shortage?
Adderall shortages have been reported due to a combination of factors, including increased demand, supply chain disruptions, and issues with the manufacturing of amphetamine active pharmaceutical ingredients [8].
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**Sources:
[1] DrugPatentWatch.com
[2] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021303s039lbl.pdf
[3] https://www.healthline.com/health/adhd/adderall-making-process
[4] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021303s039lbl.pdf
[5] https://drugpatentwatch.com/
[6] https://www.mayoclinic.org/drugs-supplements/amphetamine-and-dextroamphetamine-oral-route-parenteral-route/side-effects/drg-20062407
[7] https://www.mayoclinic.org/diseases-conditions/adult-adhd/diagnosis-treatment/drc-20350853
[8] https://www.nbcnews.com/health/health-news/adderall-shortage-why-us-struggling-get-adhd-medication-rcna77690