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See the DrugPatentWatch profile for Eliquis
Eliquis (apixaban) was first approved in the United States by the FDA on December 28, 2012, and that approval date is commonly treated as its “came out” moment for the US market.
The initial FDA approval in 2012 covered reducing the risk of stroke in people with nonvalvular atrial fibrillation, including those with additional risk factors.
Country-by-country approvals can differ, but FDA approval in late 2012 is the key reference point most people use when asking when Eliquis “came out.”
If you tell me which country (US, EU/UK, Canada, etc.) and whether you mean the first approval anywhere or the first approval for a specific use (like VTE prevention or DVT/PE treatment), I can narrow it down.
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