Combining ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), with a monoamine oxidase inhibitor (MAOI) antidepressant can pose several risks due to potential interactions between the two medications.

This interaction is a concern because both ibuprofen and MAOIs affect the body's levels of certain chemicals. Ibuprofen can increase the levels of serotonin and norepinephrine in the body, while MAOIs primarily work by inhibiting the enzyme that breaks down these same neurotransmitters. The combination of these effects can lead to excessive levels of serotonin and norepinephrine, which can cause serotonin syndrome or a potentially life-threatening condition known as malignant hyperthermia [1].


Ibuprofen can also exacerbate the increased risk of bleeding that comes with MAOI therapy. MAOIs inhibit the enzyme responsible for breaking down a compound called serotonin that in the blood vessels. MAOIs may increase the risk of bleeding in patients with certain medical conditions. Combining MAOIs with ibuprofen may increase the risk of bleeding due to their additive effect on the body's clotting mechanisms [2].

The risks associated with combining ibuprofen and MAOIs can be managed through careful monitoring and adherence to the guidance of a healthcare professional. Patients taking MAOIs and ibuprofen simultaneously should be closely monitored for signs and symptoms of serotonin syndrome, such as fever, muscle weakness, confusion, shivering, and sweating, as these symptoms can be life-threatening.

For those taking the MAOIs and ibuprofen combination, it is also essential to inform the healthcare provider of any medications, including supplements and over-the-counter medications, that are being taken alongside the prescribed medications. This will help minimize the risk of adverse interactions and ensure the patient receives the best possible care [3].

Sources:

[1] https://www.drugpatentwatch.com
[2] https://www.drugbank.ca/drugs/DB00973
[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC444133/