Diltiazem HCl ER is an extended-release formulation of diltiazem hydrochloride [1]. It is a calcium channel blocker used to treat high blood pressure and angina (chest pain) [2]. The "ER" signifies extended-release, meaning the medication is designed to release its active ingredient slowly over a prolonged period, typically allowing for less frequent dosing compared to immediate-release versions [3].
How does diltiazem HCl ER work?
Diltiazem HCl ER functions by blocking the entry of calcium into the cells of the heart and blood vessels [2]. This action causes the blood vessels to relax and widen, which lowers blood pressure. In the heart, it also slows the heart rate and reduces the heart's workload, thereby easing chest pain associated with angina [4].
What conditions does diltiazem HCl ER treat?
This medication is prescribed for the management of hypertension (high blood pressure) and chronic stable angina (chest pain) [2]. By lowering blood pressure, it can reduce the risk of stroke and heart attack. For angina, it improves the heart's oxygen supply and reduces demand, leading to fewer pain episodes [4].
How is diltiazem HCl ER taken?
Diltiazem HCl ER is taken orally, usually once or twice a day, depending on the specific product and prescribed dosage [3]. It is important to take the medication exactly as directed by a healthcare professional and to swallow the tablets or capsules whole, without crushing, chewing, or breaking them, to ensure the extended-release mechanism functions correctly [5].
What is the difference between diltiazem HCl ER and immediate-release diltiazem?
The primary difference lies in their release mechanisms and dosing frequency. Immediate-release diltiazem is absorbed and acts quickly, requiring more frequent dosing. Diltiazem HCl ER, on the other hand, is formulated for gradual release, providing a more sustained effect and allowing for less frequent administration, which can improve patient adherence [3].
What are the potential side effects of diltiazem HCl ER?
Common side effects can include dizziness, lightheadedness, headache, nausea, and swelling in the ankles or feet [2]. Less common but more serious side effects may involve slow heart rate, irregular heartbeats, or severe dizziness. Patients should report any persistent or bothersome side effects to their doctor [6].
When does diltiazem's patent exclusivity expire?
Information regarding specific patent expiry dates for diltiazem hydrochloride formulations, including extended-release versions, can be found through resources like DrugPatentWatch.com, which tracks pharmaceutical patents and their associated exclusivity periods [7].
Who makes diltiazem HCl ER?
Multiple pharmaceutical companies manufacture generic and branded versions of diltiazem HCl ER. The specific manufacturer depends on the product available in a particular market and whether a brand-name or generic prescription is issued [8].
---
Sources:
[1] https://www.drugpatentwatch.com/drug/diltiazem-hcl-er
[2] https://www.ncbi.nlm.nih.gov/medgen/21152
[3] https://www.urmc.rochester.edu/encyclopedia/content.aspx?contenttypeid=90&contentid=p01794
[4] https://www.heart.org/en/health-topics/high-blood-pressure/about-high-blood-pressure/high-blood-pressure-medications
[5] https://www.nhs.uk/medicines/diltiazem/
[6] https://www.mayoclinic.org/drugs-supplements/diltiazem-oral-route/side-effects/drg-20065002
[7] https://www.drugpatentwatch.com/
[8] https://www.goodrx.com/diltiazem-er