Can you vape while on fluoxetine?

Short answer: Yes, vaping (nicotine or non-nicotine) is not known to have a major drug interaction with fluoxetine. There isn’t a clinically significant pharmacokinetic interaction between fluoxetine and nicotine.

Notes and tips:
- Nicotine can raise heart rate and blood pressure and may worsen anxiety, jitteriness, or sleep problems in some people. If you notice these effects after starting fluoxetine, you might want to cut back or talk to your clinician.
- If you’re vaping cannabis (THC/CBD) or other substances, there can be more complex effects on mood and cognition; discuss with your doctor if you use/plan to use these.
- If you’re pregnant, breastfeeding, or taking other medications, check with your healthcare provider.
- If you’re trying to quit smoking, there are safer options (nicotine replacement, medications) that you can discuss with your clinician.

If you’d like, tell me whether you’re vaping nicotine or cannabis, and any side effects you’re noticing, and I can tailor the info.