The generic version of pregabalin is available and marketed under the name pregabalin. It is an anticonvulsant and nerve pain medication used to treat epilepsy, neuropathic pain, fibromyalgia, and generalized anxiety disorder [1].
When did pregabalin go off-patent?
The exclusivity for pregabalin, originally marketed as Lyrica by Pfizer, began to expire in various regions. In the United States, the patent expiry and subsequent market entry of generic versions occurred around July 2019 [2]. Similar expirations have led to the availability of generic pregabalin in other markets.
Who makes generic pregabalin?
Multiple pharmaceutical companies manufacture and distribute generic pregabalin. These include companies like Teva Pharmaceuticals, Sun Pharmaceutical Industries, Mylan N.V. (now part of Viatris), and Aurobindo Pharma, among others, in various global markets [3].
How does generic pregabalin differ from brand-name Lyrica?
Generic pregabalin is bioequivalent to brand-name Lyrica, meaning it has the same active ingredient, dosage form, strength, route of administration, and intended use. The primary differences lie in the inactive ingredients, such as binders, fillers, and dyes, which do not affect the drug's safety or efficacy. The cost is also a significant difference, with generic versions typically being much less expensive than the brand-name drug [4].
What is the cost of generic pregabalin?
The cost of generic pregabalin varies depending on the dosage, quantity, and the specific pharmacy or distributor. However, it is generally substantially lower than the cost of branded Lyrica. Prices can range from a few dollars to tens of dollars per prescription, depending on insurance coverage and pharmacy pricing [5].
What are the potential side effects of pregabalin?
Common side effects associated with pregabalin include dizziness, drowsiness, fatigue, and dry mouth. Less common side effects can include weight gain, blurred vision, swelling in the hands or feet, and problems with coordination [6]. Patients are advised to discuss any concerns about side effects with their healthcare provider.
Are there any risks associated with stopping pregabalin?
Abruptly stopping pregabalin can lead to withdrawal symptoms, which may include anxiety, insomnia, nausea, pain, and sweating. It is recommended that patients gradually reduce their dosage under the supervision of a healthcare professional to minimize these risks [7].