Supplements can potentially reduce the effectiveness of Lipitor, a medication commonly prescribed to manage high cholesterol levels. According to a study reported by NPR [${2}], supplements were found to be less effective than statins like Lipitor in reducing cholesterol.

The active ingredient in Lipitor is atorvastatin, which works by blocking a specific enzyme in the body that is needed to make cholesterol [${1}]. When supplements are taken alongside Lipitor, they may interfere with the drug's ability to inhibit this enzyme, thereby reducing the medication's effectiveness.

It is worth noting that certain supplements, such as red yeast rice, contain a natural form of statins [${2}]. While these supplements may help lower cholesterol levels, they can also interact with prescription statins like Lipitor and increase the risk of side effects.

It is essential to consult with a healthcare provider before combining any supplements with prescription medications like Lipitor. A healthcare provider can provide guidance on potential interactions and help ensure the safe and effective use of both supplements and medications.

Sources:

* <https://www.drugpatentwatch.com/p/tradename/LIPITOR>
* <https://www.npr.org/sections/health-shots/2022/11/06/1134094540/statins-vs-supplements-new-study-finds-one-is-vastly-superior-to-cut-cholesterol>
* <https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/in-depth/statin-side-effects/art-20046013>