Is there a patent specifically for “sorafenib synthesis” using an isocyanate–aniline route?
I can’t confirm any specific patent from the information provided. The query sounds like it’s looking for patent coverage related to a particular synthetic approach (using an isocyanate and an aniline as key building blocks) for making sorafenib, but no patent number, assignee, jurisdiction, or citation details were included.
If you share any of the following, I can help you narrow to the right patent documents and summarize what they claim:
- at least one patent number or application number
- company/assignee name (e.g., Bayer, Onyx, etc.)
- the jurisdiction (WO/EP/US/CN)
- the specific intermediate names (the isocyanate and aniline identity, or any named intermediate)
- a linker description (what gets formed from the isocyanate–aniline pair)
What patents generally cover sorafenib synthesis (at a high level)?
Sorafenib (a small-molecule kinase inhibitor) is typically protected by a mix of patent types:
- compound claims on sorafenib itself (and close analogs)
- process claims on making sorafenib (often limited to particular intermediates, reaction conditions, or order of steps)
- intermediate and intermediate-use claims tied to specific synthetic routes
Process patents are where an “isocyanate + aniline” concept would most plausibly appear: claims might focus on forming a urea/carbamate-type linkage from an isocyanate with an aniline, or on how that linkage is made/controlled to reach a specific sorafenib intermediate.
How do you search for “isocyanate aniline” process patents for sorafenib?
A targeted patent search usually combines sorafenib terms with reaction-building-block terms. Common keyword themes to use:
- “sorafenib” + “isocyanate”
- “sorafenib” + “aniline”
- “sorafenib” + “urea” (if the isocyanate–aniline step forms a urea)
- “sorafenib” + “carbamoyl” or “carbamate” (if the product linkage is a carbamate/related motif)
- names of likely intermediates (if you know them)
In patent databases, it also helps to search by:
- assignee/company
- publication date range (especially around when key process filings were made)
- classification codes for pharmaceuticals/organic synthesis (if you have access to IPC/CPC filters)
Could this be confused with general isocyanate–aniline chemistry patents (not sorafenib-specific)?
Yes. Many patents broadly cover isocyanate–aniline couplings and urea/carbamate formation for various targets. Those documents may mention “sorafenib” only as one example or may not claim the sorafenib route specifically. That’s why you need at least one anchor detail (patent number, assignee, or intermediate name) to distinguish sorafenib-specific process claims from generic reaction methodology.
What happens if you only have “isocyanate aniline” but not the intermediate?
Without intermediate identity or a reaction-step description (what bond is formed and at what stage), it’s hard to determine:
- whether the claimed chemistry is actually for sorafenib (versus an unrelated scaffold)
- whether the patent covers the specific isocyanate + aniline combination you mean
- whether it covers an alternative route or only a narrow set of conditions
Next step: tell me one concrete detail so I can find the right patent(s)
Reply with any one of these, and I’ll tailor the answer to the exact patents:
1) a patent number/application number or a link you saw
2) the isocyanate name and aniline name (or what functional group they introduce)
3) the key intermediate you think is formed using the isocyanate–aniline step
4) the assignee/company you suspect filed it
Sources
No sources were provided in your prompt, and none can be cited reliably without the patent documents (numbers or links).