It is generally safe to take painkillers while on Lipitor (atorvastatin), but it is advisable to consult with a healthcare professional or pharmacist before combining medications. The British Heart Foundation suggests that certain painkillers, like ibuprofen, can interact with statins like Lipitor, potentially affecting the statin's effectiveness. The NHS also recommends caution with non-steroidal anti-inflammatory drugs (NSAIDs) when taking atorvastatin. It is essential to seek professional advice to ensure the safe and effective use of both medications simultaneously. [2][3]

Sources:
[2] https://www.nhs.uk/medicines/atorvastatin/taking-atorvastatin-with-other-medicines-and-herbal-supplements/
[3] https://www.bhf.org.uk/informationsupport/heart-matters-magazine/medical/drug-cabinet/statins